Bupropion hcl xl and weight loss
Suicidal behavior is less of a concern when bupropion is prescribed for smoking cessation. Epileptic seizures are the most important adverse effect of bupropion. In 2009 the FDA issued a health advisory warning that the prescription of bupropion for smoking cessation has been associated with reports about unusual behavior changes, agitation and hostility. A high incidence of seizures was responsible for the temporary withdrawal of the drug from the market between 1986 and 1989. Questions and Answers on Draft Guidance for Industry: Medication Guides - Distribution Requirements and Inclusion in REMS. Postmarket Drug Safety Information for Patients and Providers. Bupropion was first made by Nariman Mehta and patented by Burroughs Wellcome in 1969, which later became part of what is now GlaxoSmithKline. Since bupropion is metabolized to hydroxybupropion by the CYP2B6 enzyme, drug interactions with CYP2B6 inhibitors are possible: this includes medications like paroxetine, sertraline, fluoxetine, diazepam, clopidogrel, and orphenadrine. The guides address issues that are specific to particular drugs and drug classes, and they contain FDA-approved information that can help patients avoid serious adverse events. This website has been translated to Spanish from English, and is updated often. The biological activity of bupropion can be attributed to a significant degree to its active metabolites, in particular to S,S -hydroxybupropion.
The risk of seizure is strongly dose-dependent, but also dependent on the preparation. Approximately 540,000 people were treated with bupropion for smoking cessation during that period. The prescribing information notes that hypertension, sometimes severe, was observed in some patients, both with and without pre-existing hypertension. The expected result is the increase of bupropion and decrease of hydroxybupropion blood concentration. Get email alerts when the Medication Guides page is updated. Suicidal thoughts and behaviors are rare in clinical trials, and the FDA requires all antidepressants, including bupropion, to carry a boxed warning stating that antidepressants may increase the risk of suicide in persons younger than 25. See also: List of side effects of bupropion. Public Hearing on Use of Medication Guides to Distribute Drug Risk Information to Patients June 12-13, 2007. A typical bupropion treatment course lasts up to twelve weeks, with the people halting the use of tobacco about ten days into the course. It was first approved for medical use in the United States in 1989. It should be avoided in individuals who are also taking monoamine oxidase inhibitors (MAOIs). Medication Guides are paper handouts that come with many prescription medicines.
